2 Favorite Characters Leave PC, 2 Villains Return With Dangerous Plots! | General Hospital Spoilers

Port Charles is about to be shaken to its core as the next chapter of General Hospital unfolds. The quiet calm that has settled over town is nothing but an illusion — a deceptive peace that’s about to be shattered by the return of two of the most dangerous figures in the show’s history. And while two beloved characters prepare to say their goodbyes, darkness creeps back into the city with deadly precision.

As the second week of November arrives, General Hospital spoilers hint that chaos is once again brewing. The first warning sign comes in the form of a name that many in Port Charles hoped they would never hear again — Pascal. His reputation as a master manipulator and cold-hearted criminal has left a trail of fear stretching from Europe to New York. Years ago, he vanished after the WSB dismantled his empire at the Five Poppies Resort in Croatia — a supposed paradise that hid a network of trafficking and espionage beneath its polished exterior.

Pascal was never just another villain. He was a strategist, a man who understood the psychology of fear and could destroy lives without lifting a finger. His involvement in the kidnapping of Josslyn Jax and Vaughn years ago left deep scars on those who survived. But now, he’s back — hiding in plain sight under a new identity as the discreet and soft-spoken house manager for Jen Sidwell at Wyndemere.

To the untrained eye, Pascal seems like a reformed man — polite, efficient, and unassuming. But those who’ve faced him before know better. His return isn’t random. It’s deliberate, calculated, and deeply personal. Beneath his calm exterior lies a vengeful storm, one that has been brewing for years.

Among his unfinished business is Dr. Britt Westbourne, who once worked for him without realizing the depth of his crimes. When Britt exposed fragments of his criminal operation, Pascal swore vengeance. And now that fate has drawn them back into each other’s orbit at Wyndemere, Britt begins to realize that her peace was only temporary. She knows the look in Pascal’s eyes — the same look that once promised torment.

Meanwhile, Josslyn Jax has grown stronger since her ordeal. No longer the frightened girl from Croatia, she’s now a skilled WSB operative determined to eliminate Pascal once and for all. Her mission is clear, but the reality of facing the man who once terrorized her shakes even her confidence. Pascal is always two steps ahead. He’s turned fear into a weapon sharper than any knife, and Josslyn’s every move seems to fall right into his carefully laid trap.

Adding to the growing tension is Pascal’s new ally — Professor Henry Dalton, a brilliant scientist whose moral compass has long since eroded. On the surface, Dalton is a respected academic in biochemical research. But beneath the surface, he’s dangerously ambitious and easily manipulated. Pascal lures him into what seems like a groundbreaking scientific partnership. In truth, Dalton is unknowingly helping develop a biotoxin capable of killing silently and leaving no trace.

The mastermind behind it all remains unseen — the mysterious figure known only as C, the same puppet master who once controlled Pascal. Dalton doesn’t realize that every discovery he makes, every formula he refines, is feeding into C’s secret agenda. And worse, Pascal has already been ordered to dispose of Dalton once his work is complete.

As Pascal’s deadly plot unfolds, tragedy strikes elsewhere in Port Charles. Two beloved figures are preparing to leave — and their exits mark the end of an era.

Veronica “Ronnie” Bard decides it’s time to step away from the chaos. Following the death of Monica Quartermaine, Ronnie is left adrift in the silence of the Quartermaine mansion. The estate that once symbolized power and family now feels like a tomb of unspoken regrets. Monica’s will leaves Ronnie enough to start anew, and after much soul-searching, she decides to leave Port Charles quietly. Her goodbye is heartfelt, simple, and deeply emotional. “If you ever need me, I’ll come back,” she tells Tracy and Brook Lynn. But everyone watching knows that sometimes goodbyes in Port Charles are forever.

Her departure leaves a hole in the Quartermaine family’s heart — but before they can heal, tragedy strikes again. During a heated confrontation with Drew Cain over ELQ and family loyalty, Ned Quartermaine suddenly collapses. At first, it looks like a heart attack brought on by stress — but the test results tell a different story. Doctors detect traces of a toxin in Ned’s system, one eerily similar to the biochemicals once used in Pascal’s Croatian experiments.

The discovery sets off alarm bells across Port Charles. Could Ned’s collapse be tied to Pascal’s return? The WSB begins a quiet investigation, and Josslyn quickly connects the dots — Dalton’s research, Pascal’s presence at Wyndemere, and now Ned’s poisoning can’t be coincidences.

Meanwhile, Olivia Quartermaine refuses to believe Ned’s condition is natural. She hires an independent toxicologist who confirms her worst fears: the poison in Ned’s blood is synthetic and engineered — something that could only have come from a lab. The same type of compound that destroyed lives at the Five Poppies years ago.

Realizing the truth, Josslyn reaches out to Britt, who’s been secretly investigating Pascal on her own. Together, they uncover a USB drive left behind by Dalton — recordings and data proving Pascal’s plan to test his biotoxin in Port Charles before releasing it on a global scale. The two women form an uneasy alliance, bound by the need to stop Pascal before phase two begins.

But Pascal is already one step ahead. He manipulates Britt into walking straight into a trap deep beneath Wyndemere. There, in the dimly lit tunnels once used by the Cassadines, Pascal confronts her face-to-face. The air is thick with tension as he taunts her for wasting her brilliance. “You were never meant for saving lives,” he says coldly. “You were meant for power.”

Britt refuses to break, but when Josslyn loses contact with her, she knows Pascal has struck again. The WSB storms Wyndemere, but Pascal is gone — vanished like smoke. Britt is missing, Sidwell lies unconscious in his office, and a chilling note is pinned to his desk: “Phase Two.”

In the aftermath, Port Charles is left reeling. Ned remains in a coma, Ronnie’s gone, and the Quartermaine mansion feels emptier than ever. Olivia clings to hope while Brook Lynn’s faith begins to crumble. The once-proud family is fractured, their future uncertain.

And somewhere in the shadows, Pascal watches — patient, calm, and ready. He’s already begun preparing the next phase under his master’s orders. In a hidden lab lit by the faint glow of chemical vials, Pascal reports to C. “The trial was successful,” he says. “The next phase will begin soon.”

The voice on the other end replies, smooth and chilling: “Then Port Charles won’t know what hit it.”

As he ends the call, Pascal opens a case containing a vial of glowing toxin — perfected, silent, and deadly. He smiles, knowing that his true reign of terror is only beginning.

Unaware of the storm looming above, Port Charles sleeps. The lines between loyalty and betrayal, love and death, blur once more. When morning comes, the heroes of General Hospital will awaken to a town forever changed — and one ruthless villain already planning his next strike.

Because Pascal’s return isn’t just about revenge. It’s about power, control, and chaos. And this time, not everyone will survive what’s coming next.